Prompting structure stability of O3–NaNi0.5Mn0.5O2 via effective surface regulation based on atomic layer deposition

Layered O3 type oxides exhibit promising prospects as high-performance cathodes for sodium-ion batteries (SIBs) due to their low cost and high theoretical capacities. Nevertheless, the intrinsic surface composition and bulk structure degradation upon cycling presents a huge obstacle to stable sodium-ion storage/transportation. Besides, the effective surface decoration on layered O3 oxides is still challenging through conventional wet chemical route owing to their extraordinarily high surface sensitivities. Herein, a typical O3 type layered oxide of NaNi_0.5Mn_0.5O₂ (NNMO) was selected and successfully encapsulated by precisely controlled Al₂O₃ layers via atomic layer deposition (ALD) technology. With the optimally controlled Al₂O₃ thickness of 3 nm, the surface regulated NNMO delivers a highly reversible capacity of 73.6 mA h g^-1, with a significantly improved capacity retention of 68.0% after 300 cycles at 0.5 C, and a superior rate capability of 65.8 mA h g^-1 at 10 C. Further air sensitivity tests demonstrate that the protective layer could effectively mitigate the generation of sodium-based impurities on NNMO, and reduce the surface sensitivities. Both chemical and electrochemical aging tests confirm the contribution of Al₂O₃ coating layer in alleviating ion dissolution as well as stabilizing the structure and morphology of NNMO. Based on regulating the surface of O3 type layered oxides utilizing ALD technique, this work supplies an effective and facile strategy to overcome the challenges from fast structure degradation and electrochemical property decay, which not only highlights the significance and effectiveness of surface engineering in secondary batteries, but also sheds light on accurate interface construction and regulation for active electrode materials, particularly for those sensitive to ambient atmosphere.     

Improved synergetic excitation control for transient stability enhancement and voltage regulation of power systems

This paper proposes decentralized improved synergetic excitation controllers (ISEC) for synchronous generators to enhance transient stability and obtain satisfactory voltage regulation performance of power systems. Each generator is considered as a subsystem, for which an ISEC is designed. According to the control objectives, a manifold, which is a linear combination of the deviation of generator terminal voltage, rotor speed and active power, is chosen for the design of ISEC. Compared with the conventional synergetic excitation controller (CSEC), a parameter adaptation scheme is proposed for updating the controller parameter online in order to improve the transient stability and voltage regulation performance simultaneously under various operating conditions. Case studies are undertaken on a single-machine infinite-bus power system and a two-area four-machine power system, respectively. Simulation results show the ISEC can provide better damping and voltage regulation performance, compared with the CSEC without parameter adaptation scheme and the conventional power system stabilizer.     

microRNA在亨廷顿病中的研究进展

亨廷顿病(Huntington's disease, HD)是神经退行性疾病(neurodegenerative disorders)中一种单基因遗传病,由亨廷顿基因(the huntingtin gene, HTT)第一个外显子中的CAG三核苷酸序列重复扩增引起,尚无法治愈。HTT编码的蛋白产物被称为亨廷顿蛋白(Huntingtin protein, Htt)。突变亨廷顿蛋白(mutated huntingtin protein, mHtt)容易形成聚集体,具有毒性,导致一系列细胞学异常和神经元功能障碍。microRNA(miRNA)在基因转录后水平调控中起重要作用,其表达的改变与HD病理过程有关,成为治疗HD的潜在生物标志物。近年来,对一些特定miRNA在HD中调控机制及靶基因预测方面的研究可为HD提供潜在的治疗方法。本文就miRNA在HD中的相关研究进展进行综述。     

Metabolism of phospholipids in the yeast Schizosaccharomyces pombe

The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water-soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value-added lipid molecules.     

Reexamination of the Ergothioneine Biosynthetic Methyltransferase EgtD from Mycobacterium tuberculosis as a Protein Kinase Substrate

Ergothioneine has emerged as a crucial cytoprotectant in the pathogenic lifestyle of Mycobacterium tuberculosis. Production of this antioxidant from primary metabolites may be regulated by phosphorylation of Thr213 in the active site of the methyltransferase EgtD. The structure of mycobacterial EgtD suggests that this post-translational modification would require a large-scale change in conformation to make the active-site residue accessible to a protein kinase. In this report, we show that, under in vitro conditions, EgtD is not a substrate of protein kinase PknD.     

基于ＰＩＤ控制算法的直流微网容错控制方法研究

构建直流微网容错控制对象模型，调节直流微电网的输出回路参数；以输出功率、直流微网的 参考电压、弱电网下系统惯性响应特征等为约束参量，构建直流微网容错控制目标函数，在不同电网强度下 进行直流微网容错控制的参数自整定性调节，采用无功环比例积分控制方法进行直流微网容错寻优分析， 建立模糊 ＰＩＤ控制模型，采用变结构的模糊 ＰＩＤ控制方法进行直流微网容错控制过程中的自适应加权学习 和误差反馈调节，实现直流微网容错控制改进设计。仿真结果表明，采用该方法进行直流微网控制的容错 性能较好，输出稳定性较强，具有较好的直流微网输出增益。     

"十五"期间水电前期工作取得重要成就

“十五”是我国水电建设发展最快、成绩最大的重要时期。在党的十六大精神和国家大力发展水电方针的指引下,水电前期工作取得了重要成就。“十五”期末,已经完成和正在开展的预可行性研究项目53项,总装机容量约9 000万kW;可行性研究项目35项,总装机容量约4 000万kW。完成了全国水力资源复查工作,开展了大江大河河流(河段)的水电规划工作,谱写了水电前期工作的新篇章。     

隔河岩水电厂现地控制单元改造

结合隔河岩水电厂现地控制单元改造工程项目，依据多年的计算机监控 系统研制开发经验，对计算机监控系统现地控制单元的结构特点、技术路线及实现方法等进 行了探讨。